When you are in a hurry and need to generate data fast, DeltaPi-4 is your choice.īoth instruments measure surface tension with Kibron’s thin wire probes (DyneProbes) from small subphase volumes. Further, the choice of materials eliminates unwanted non-specific surface effects.ĭeltaPi is a single-channel model, while DeltaPi-4 is equipped with four parallel microbalances, increasing significantly the throughput of experiments. One milligram of an antimicrobial peptide, for instance, is sufficient for a comprehensive characterization of its lipid-binding properties. The volume of the magnetically stirred subphase is minimally 150 microliters, which keeps your material consumption very low.
DELTAGRAPH 6 SERIES
Along similar lines, recent findings have demonstrated the key role of lipid membranes in promoting the formation of toxic oligomers by Alzheimer Abeta peptide, prions, alpha-synuclein, and IAPP (amylin).ĭeltaPi series of Langmuir-tensiometers allow you to detect the penetration of drugs, peptides/proteins and nucleic acids into monolayers of specified lipid composition and at precisely controlled lateral packing density. phosphatidylinositols (PIPs) in controlling cytoskeleton-membrane interactions. Drug-lipid and protein-lipid interactions have emerged as a new, very exciting area in drug discovery, deciphering the roles of e.g. In these studies lipid monolayers have paved way to breakthroughs in the elucidation of the molecular mechanisms of action of lung surfactants, antimicrobial peptides, lipid signaling, blood coagulation, and cell adhesion, just to name a few examples. We innovate instruments for your innovative science.īiomembranes and lipids are entering the forefront of biosciences, biotechnology and drug discovery. Kibron DeltaPi and DeltaPi-4 are novel types of instruments: Langmuir-tensiometers, which allow you to measure the binding of drugs, peptides, and proteins to lipid membranes – easily and with unparalled sensitivity. I started my career in 1981 working for 3 years at a defense contractor.Kibron’s unique single and 4-channel Langmuir-tensiometers
DELTAGRAPH 6 MAC
It shipped in January 1987 but by the end of the year we sold it and then I started a new company to just develop for other people.īy 1985 I started my first company to develop and then sell a spreadsheet like application for the Mac called Trapeze. We worked on the presentation app Persuasion (for the author) and then spent 6 years working on Deltagraph for its publisher. So what was it like back then in the dark ages? Quite different than today in many ways not so different in others. I quit my job in late 1984 and then came up with the idea that became Trapeze. Like any young person with an idea I got people I knew excited and we got a group of investors together. As it is today there were people who liked to invest in new ideas but unlike today many of them had no idea what we were doing.
DELTAGRAPH 6 SOFTWARE
I remember talking with a banker who upon hearing we were going to work on software thought we were making lingerie! The whole idea of software was unfamiliar to many.
There was little email (at my first job I had an email address outside of work but I only knew one person with one - my boss - and we sat next to each other at work) and of course no internet. Learning meant libraries, or magazines, or maybe a user group. If you wanted to know what a piece of software did you had to buy a copy.
Just finding out what software existed meant reading ads or magazine reviews or a computer show. We had two 512K Macs and one Mac XL (a Lisa running MacOS) that had a small hard drive we all shared. I used the XL and the other two developers could access the hard drive over Appletalk. At first we used some C compiler who's name I don't remember, it was pretty slow. The linker spent most of its time drawing icons on the screen.
At some point we started using Lightspeed-C (later named Think C) which helped a lot.
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